MSR Houston is located 35 minutes south of Downtown Houston on Highway 288. We are exactly 13 miles south of State Hwy 6 on the left hand side of the highway. Traveling south on Hwy 288, exit SOUTH CR 48. SOUTH CR 48 is located just after the FM 1462/Rosharon exit.
| Location | Travel Time |
| Texas Gulf Coast Regional Airport | 15 minutes |
| Houston Hobby Airport (HOU) | 30 minutes |
| Sugar Land | 35 minutes |
| Galleria | 35 minutes |
| Downtown Houston | 35 minutes |
| Clear Lake | 40 minutes |
| Bush Intercontinental Airport (IAH) | 50 minutes |
| The Woodlands | 60 minutes |